Affimer technology offers unique solutions in the field of affinity purification through the ability to develop highly specific and stable capture reagents for a wide-range of novel targets. The robust nature of Affimer reagents allows them to withstand industrial cleaning-in-place conditions without significant leaching, while highly reproducible manufacturing assures the consistency of supply. Affimer reagents can be engineered to orient the binder on the resin to optimise target binding. Implementing Affimer reagents in affinity chromatography and bioprocessing applications opens up the potential of unmet needs in this field.