Antioxidants, long touted in cosmeceuticals for their anti-aging miracles, and in food industries for their health benefits, are now a new dynamic component in IVF media. While it has been demonstrated that the use of individual antioxidants has beneficial effects, their real power is manifest when used in combination, as is seen in vivo as part of an elegant antioxidant system. This blog post outlines the rationale for including antioxidants in IVF media and how the three antioxidants in the Gx Media system were selected and tested in the mouse model.
Gametes and embryos are exposed to oxidative stress in vitro
Exposure to 20% (atmospheric) oxygen has been shown to be a source of oxidative stress detrimental to the development of gametes and embryos. Although there are many well documented pathologies associated with culture at atmospheric oxygen [1, 2], it is still not uncommon for IVF clinics to utilise 20% oxygen in all or part of their human embryo culture system.
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