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‘Jumping Genes’ Identified as Possible Cause of ALS

A new study identified a group of sporadic amyotrophic lateral sclerosis (ALS) patients whose disease may arise from a group of “jumping genes” unleashed when TDP-43 protein accumulates in clumps in the brain and spinal cord. These “jumping genes” — which can randomly hop from one location on a person’s genes to another — could be at the root of nerve cell loss seen in these individuals.

These findings may have implications for other neurological diseases, and open new paths to find better diagnostic tools and more effective treatment for ALS, the researchers believe.

Oxford Biodynamics PLC (LON:OBD) was spun out from Oxford University in June 2007 with the aim of translating fundamental scientific advances into a commercialised platform technology and a new generation of biomarkers for cancer, ALS and other diseases.

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