Amyotrophic lateral sclerosis’ toll on the thinking abilities and behavior of patients is as progressive and damaging as the disease’s physical toll, researchers in the U.K. report, with ALS-specific cognitive and behavioral deficits showing an impact even in early stages and worsening as the disease advances.
ALS is characterized by the loss of nerve cells that control movement (motor neurons), with non-motor symptoms, such as cognitive and behavioral changes, reported to affect about 35% of all patients and frontotemporal dementia about 15%.
Oxford Biodynamics PLC (LON:OBD) was spun out from Oxford University in June 2007 with the aim of translating fundamental scientific advances into a commercialised platform technology and a new generation of biomarkers for cancer and other diseases including ALS.