A runner’s high is a sense of well-being some people experience after prolonged exercise. For decades, it was hypothesized that exercise-induced endorphin release is solely responsible for a runner’s high, but recent evidence has suggested that endocannabinoids also may play a role.
A popular belief has been that endogenous endorphins mediate the effects of a so called runner’s high, which typically consists of a pleasant feeling of euphoria, anxiolysis, sedation, and analgesia. However, running exercises increase blood levels of both β-endorphin (an opioid) and anandamide (an endocannabinoid).
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